Pluronic P85 decreases the delivery of phenytoin to the brain in drug-resistant rats with P-glycoprotein overexpressed chronic mesial temporal lobe epilepsy

P-glycoprotein (Pgp) overexpressed in blood brain barrier (BBB) is hypothesized to lower drug concentrations and thus inhibit anticonvulsant effects drug-resistant epilepsy. Pluronic P85 (P85) was proved enhance the delivery of drugs into by inhibition Pgp. To determine whether surfactant [versus Pgp inhibitor tariquidar (TQD)] phenytoin (PHT) rats with chronic mesial temporal lobe epilepsy (MTLE) induced lithium-pilocarpine, which were overexpressed, then direct verification PHT transport via measurement concentration using microdialysis. The model randomly divided three groups, treated PHT, 1%P85+PHT, or PHT+TQD, respectively. 1%P85+PHT treatment displayed a ratio area under curve (AUC) brain/plasma even than that (p < 0.05), while PHT+TQD showed highest AUC all treatments. However, liver/plasma similar groups > 0.05). For kidney/plasma, group had other treatments rats. Thus, oppositely decreased MTLE TQD could increase distribution brain.